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The depletion of transmembrane 7 superfamily member 2 (TM7SF2), a key regulator of cholesterol biosynthesis, results in the increased expression of FA catabolic enzymes accompanied by decreased lipid accumulation, autophagy, and tissue injury in mice exposed to endotoxin ( de novo sphingolipid biosynthesis is essential for autophagy induction in macrophages, which plays a protective role by clearing excess lipids from LDs through the turnover of ORMDL sphingolipid biosynthesis regulator 1 (ORMDL1) protein, a negative regulator of serine palmitoyl-CoA transferase activity (Wang et al., 2015b)

The anti-SARS-CoV-2 activity determination was supported by ERDF/ESF project ChemBioDrug CZ.02.1.01/0.0/0.0/16_019/0000729 and the Institute of Organic Chemistry and Biochemistry of the CAS (RVO 61388963)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 81.Boesch-Saadatmandi C., Wagner A.E., Graeser A.C., Hundhausen C., Wolffram S., Rimbach G